![]() ![]() More comparative studies are needed before evidence-based protocols can be developed.Ībstract = "For knee osteoarthritis and related conditions, analysis of biomarkers hold promise to improve early diagnosis and/or offer patient-specific treatment. Further evidence regarding needle size, ultrasound-guidance and mechanical compression were found. Suggestions were compiled for arthrocentesis regarding approach portal and patient position. Sample quantity ranged approximately from 2 to 20. Single-handed tools were preconized, including Parker-Pearson needles and forceps. ![]() For blind and image-guided synovial biopsy techniques, superolateral and infrapatellar approaches were recommended. 18-gage needles, mechanical compression and ultrasound-guidance were found to give superior results. ![]() For arthrocentesis, the superolateral approach in a supine position, with a 0°-30° knee flexion was generally recommended. Thirty-one studies were identified for inclusion. Expert recommendations and applications were summarized, and evidence for superiority of techniques was evaluated. Therefore, PubMed, Embase and Web of Science were systematically searched for articles that applied, demonstrated, or evaluated synovial biopsies or arthrocentesis. The aim of this work is to summarize the literature on the current best practices of biopsy of the synovium and synovial fluid arthrocentesis. To compare biomarker analyses, reliable, high-quality biopsies are needed. For knee osteoarthritis and related conditions, analysis of biomarkers hold promise to improve early diagnosis and/or offer patient-specific treatment. ![]()
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